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Background: Narcolepsy is a disabling sleep-wake disorder characterized by the pentad symptoms of excessive daytime sleepiness, sleep paralysis, sleep fragmentation, sleep-related hallucinations, and cataplexy. Most doctors recommend trying modafinil ( Provigil) or armodafinil. Taking baclofen for narcolepsy without cataplexy I started on Baclofen at 20mg about 7 months ago and quickly went up to 30mg and have stayed at that dose since. Turns out I have in the last few years developed sleep apnea and was stopping breathing about 15 times an hour. I felt like a normal person some days and the improvement felt much more natural than stimulants. The intensity of the symptoms can be very different from one patient to another, and some symptoms (e. Excessive sleepiness during daytime. The phase IV clinical study analyzes which people take Baclofen and have Narcolepsy. Baclofen is a centrally acting GABA-beta agonist that is frequently used in pediatric patients for the treatment of dystonia, rigidity, and spasticity, which are associated with a variety. 8 milligram per kilogram twice nightly — the same dosing regimen given to people with narcolepsy — suppressed cataplexy to a greater extent. It was the best Ive felt since being diagnosed with narcolepsy. Twenty-six narcoleptic teenagers with recent onset of narcolepsy-cataplexy sy …. A 2014 mice study found that giving R-baclofen (R-BAC) 2. Ago Narcolepsy & Cataplexy Not a good idea if you have an apnea or respiratory matter, as it is a respiratory depressant, which can be a danger. My previous sleep study from 15-20 years ago show. A number of medications can help a person stay awake. The investigators concluded that future studies are warranted,. Narcolepsy is a sleep disorder with the main manifestations of excessive daytime sleepiness, cataplexy, sleep paralysis, sleep hallucinations, and nighttime sleep disturbance. Took close to a year before the dr ordered another sleep study and had me sleep while taking xyrem. I quit vaping 6 months ago because I developed a persistent. Along with great prices, many online pharmacies regularly supply deals and discounts on Gabapentin and overnight bulk orders Treatment goals of narcolepsy therapy are directed at specific relief of symptoms, including excessive daytime sleepiness, sleep fragmentation, and cataplexy. Baclofen use in narcolepsy with cataplexy therefore warrants further investigation. There is no curative therapy for narcolepsy. Our findings suggest that baclofen could be helpful for cataplexy at moderate night-time doses, possibly in older non-adolescent patients and could be a safer and cheaper alternative to GHB. While a 2009 study by Huang and Guilleminault3 of 13 narcolepsy-cataplexy patients treated with another GABA-B agonist, baclofen, yielded negative results, a recent report in a mouse model has. Treatment is therefore symptom directed Baclofen has been studied, and as you might have read there are studies confirming that Baclofen (a GABA B agonist) does increase delta wave sleep and total sleep time. Cataplexy) may be completely absent (8). My narcolepsy symptoms improved substantially and they only improved further as the amount of nicotine I consumed increased. This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa,. After about 10 years my xyrem stopped working effectively. Treatment is therefore symptom directed Narcolepsy is found among people who take Baclofen, especially for people who are female, 50-59 old. In narcolepsy without cataplexy, the main symptom is sudden sleepiness. It does not, however, have any significant effect on cataplexy and daytime sleepyness, as Xyrem (sodium gammahydroxybutyrate) does The classic symptoms of narcolepsy include abnormal sleepiness during the day, disturbed sleep at night, hallucinations, sleep paralysis and cataplexy. It is still not fully recognized by clinicians, and many patients are often misdiagnosed with epilepsy, syncope, or mental d …. Along with great prices, many online pharmacies regularly supply deals and discounts on Gabapentin and overnight bulk orders Adverse effects associated with the use of baclofen include depression, hallucinations, dizziness, sensory disturbances, and nausea. Disclosure The authors report no conflicts of interest in this work (N1) Narcolepsy w/ Cataplexy I tried baclofen a few times and it made me a zombie the next day, even at low doses… not even my stims could shake off the zombieness.